| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:15697179 | IVR | 1 mg/kg | 1 mg/kg | Increase in corticosterone levels | Neurological endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Affects cytokine signaling | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased levels of Corticotropin-releasing hormone (CRH) | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased levels of adrenocortical hormones (ACTH) | Metabolic endocrine-mediated perturbations | |
| PMID:3975930 | IVR | 25 mg/L | 25 mg/L | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations |
| IVR | 100 mg/L | 100 mg/L | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 400 mg/L | 400 mg/L | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.