| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:11696396 | IVTH | 0.0000001 - 0.001 M | 0.00006 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:19654335 | IVR | 62.5 mg/kg/day | 62.5 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:20132880 | IVR | 62.5 mg/kg | - | No significant effects observed | - |
| IVR | 1000 mg/kg | 1000 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.