Chlorpyrifos-methyl

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15147795	IVR	250 mg/kg	250 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	-	No significant effects observed	-
	IVR	2 mg/kg	-	No significant effects observed	-
	IVR	50 mg/kg	50 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:16472551	IVR	10 mg/kg/day	10 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of adrenal gland in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Changes in adrenal gland morphology	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated pert
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of epididymis in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T4 levels
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased ovarian weights
	IVR	100 mg/kg/day	100 mg/kg/day	Affects fertility
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of thyroid gland
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T3 levels
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights
	IVR	100 mg/kg/day	100 mg/kg/day	Atrophy in seminiferous tubules
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of adrenal gland
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts
	IVR	100 mg/kg/day	100 mg/kg/day	Increased spleen weights
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased prostate weights
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testis weights
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased estradi
	IVR	100 mg/kg/day	100 mg/kg/day
	IVR	100 mg/kg/day	100 mg/kg/day
	IVR	100 mg/kg/day	100 mg/kg/day
	IVR	100 mg/kg/day	100 mg/kg/day
	IVR	100 mg/kg/day	100 mg/kg/day
PMID:23125134	IVR	100 mg/kg	100 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	4 mg/kg	4 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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