Theophylline


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:3371590IVR150 mg/kg/day 150 mg/kg/dayDecreased weights of epididymisReproductive endocrine-mediated perturbations
IVR150 mg/kg/day 150 mg/kg/dayDecreased testis weightsReproductive endocrine-mediated perturbations
IVR0.2 % 0.2 %Increased weights of epididymisReproductive endocrine-mediated perturbations
IVR75 mg/kg/day 75 mg/kg/dayAbnormal estrous cyclesReproductive endocrine-mediated perturbations
IVR0.1 % -No significant effects observed-
IVR37.5 mg/kg/day -No significant effects observed-
IVR0.3 % 0.3 %Reduced sperm countsReproductive endocrine-mediated perturbations
IVR0.3 % 0.3 %Decreased weights of seminal vesiclesReproductive endocrine-mediated perturbations
IVR0.3 % 0.3 %Increased liver weightsHepatic endocrine-mediated perturbations
IVR0.4 % 0.4 %Decreased weights of epididymisReproductive endocrine-mediated perturbations
IVR300 mg/kg/day 300 mg/kg/dayDecreased testis weightsReproductive endocrine-mediated perturbations

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