2-Ethylhexyl methoxycinnamate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15979666	IVR	275 mg	275 mg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	275 mg	275 mg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	275 mg	275 mg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	275 mg	275 mg	Alteration in vaginal morphology	Reproductive endocrine-mediated perturbations
	IVR	57.5 mg	57.5 mg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	57.5 mg	57.5 mg	Alteration in vaginal morphology	Reproductive endocrine-mediated perturbations
	IVR	57.5 mg	57.5 mg	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
PMID:16112788	IVR	1000 mg/kg	1000 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects uterine function	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	33 mg/kg	-	No significant effects observed	-
	IVR	10 mg/kg	-	No significant effects observed	-
	IVR	100 mg/kg	-	No significant effects observed	-
	IVR	333 mg/kg	333 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:17651886	IVR	1000 mg/L	1000 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	33 mg/L	-	No significant effects observed	-
	IVR	10 mg/L	-	No significant effects observed	-
	IVR	100 mg/L	-	No significant effects observed	-
	IVR	333 mg/L	333 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	333 mg/L	333 mg/L	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	333 mg/L	333 mg/L	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
PMID:18174954	IVR	12500 mg/kg	12500 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	2500 mg/kg	2500 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	2500 mg/kg	2500 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
PMID:21059369	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:28235592	IVTH	0.00001 M	0.00001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
PMID:28990245	IVTH	0.00001 M	0.00001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Induce cancer metastasis	Endocrine-mediated cancer

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.