Bisphenol A diglycidyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:12419697	IVTH	0.00000000000001 - 0.0001 M	0.00000000000001 - 0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:17426428	IVR	1500 mg/kg/day	-	No significant effects observed	-
	IVR	3000 mg/kg/day	-	No significant effects observed	-
	IVR	375 mg/kg/day	375 mg/kg/day	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Increased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Increased prostate weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Increased brain weights in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Increased weights of adrenal gland in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations

---

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.