| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10696778 | IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Decreased levels of adrenocortical hormones (ACTH) | Metabolic endocrine-mediated perturbations |
| IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Decrease in Growth Hormone (GH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Affects ovulation | Reproductive endocrine-mediated perturbations | |
| IVR | 50 - 300 mg/kg/day | 75 - 300 mg/kg/day | Decreased prolactin levels | Reproductive endocrine-mediated perturbations | |
| PMID:10746939 | IVTH | 0.000001 - 0.0001 M | 0.00003 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:11053540 | IVR | 200 mg/kg | 200 mg/kg | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 12.5 mg/kg | 12.5 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| PMID:11675267 | IVTH | 0.0000003 - 0.00003 M | 0.00003 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:12128101 | IVR | 50 mg/kg | 50 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| PMID:15056801 | IVR | 30 mg/kg | 30 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:15132767 | IVR | 5 mg/L | 5 mg/L | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/L | 5 mg/L | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/L | 500 mg/L | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| PMID:15888671 | IVR | 250 mg/kg | 250 mg/kg | Changes in T-cell populations | Immunological endocrine-mediated perturbations |
| IVR | 250 mg/kg | 250 mg/kg | Decreased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Changes in T-cell populations | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | - | No significant effects observed | - | |
| IVR | 125 mg/kg | 125 mg/kg | Changes in T-cell populations | Immunological endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| PMID:16221967 | IVR | 0.001 mg/kg/day | 0.001 mg/kg/day | Exhibit sexual dimorphism | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects neuronal density | Neurological endocrine-mediated perturbations | |
| PMID:16443249 | IVR | 0.7 mg/day | 0.7 mg/day | Changes in T-cell populations | Immunological endocrine-mediated perturbations |
| PMID:17331471 | IVTH | 0.0000001 - 0.00001 M | 0.0000001 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:17520059 | IVTH | 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:17692527 | IVR | 0.75 mg/kg/day | 0.75 mg/kg/day | Follicular atresia | Reproductive endocrine-mediated perturbations |
| IVR | 0.75 mg/kg/day | 0.75 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.75 mg/kg/day | 0.75 mg/kg/day | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Follicular atresia | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:18226067 | IVR | 0.7 mg/day | 0.7 mg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations |
| PMID:18461179 | IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects differentiation process | Developmental endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects the normal functioning of reproductive system | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Increased hCG levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:19265281 | IVR | 30 mg/kg | 30 mg/kg | Hyperplasia in mammary glands | Reproductive endocrine-mediated perturbations |
| IVR | 30 mg/kg | 30 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 3 mg/kg | - | No significant effects observed | - | |
| IVR | 100 mg/kg | 100 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Uterine atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Hyperplasia in mammary glands | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Alteration in vaginal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Affects lactation | Reproductive endocrine-mediated perturbations | |
| PMID:19365547 | IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Affects glucose metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Causes insulin resistance | Metabolic endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Affects metabolic rate | Metabolic endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg/day | 0.3 mg/kg/day | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg/day | 0.3 mg/kg/day | Affects metabolic rate | Metabolic endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg/day | 0.3 mg/kg/day | Causes insulin resistance | Metabolic endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg/day | 0.3 mg/kg/day | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg/day | 0.3 mg/kg/day | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| PMID:20045047 | IVR | 200 mg/kg | 200 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| PMID:20624442 | IVR | 1 mg/kg | 1 mg/kg | Affects testosterone metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Affects testosterone metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:21126571 | IVTH | 0.00003 M | 0.00003 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000001 M | 0.000001 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| PMID:21677308 | IVR | 200 mg/kg | 200 mg/kg | Increase in corticosterone levels | Neurological endocrine-mediated perturbations |
| IVR | 50 mg/kg | - | No significant effects observed | - | |
| IVR | 200 mg/kg | 200 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:21839517 | IVR | 50 mg/kg | 50 mg/kg | Decreased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations |
| PMID:22285353 | IVR | 200 mg/kg | 200 mg/kg | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Uterine atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects the normal functioning of reproductive system | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased uterine weights | Reproductive endocrine-media | |
| PMID:23376530 | IVR | 200 mg/kg | 200 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:24440342 | IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| PMID:24486430 | IVTH | 0.00003 M | 0.00003 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:24758756 | IVR | 154 mg/kg/day | 154 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Decreased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Decreased inhibin-B levels | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Decreased Acid phosphatase (ACP) activity in the liver | Hepatic endocrine-mediated perturbations | |
| IVR | 77 mg/kg/day | 77 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 154 mg/kg/day | 154 mg/kg/day | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 77 mg/kg/day | 77 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 77 mg/kg/day | 77 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 38.5 mg/kg/day | - | No significant effects observed | - | |
| IVR | 77 mg/kg/day | 77 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:24916741 | IVR | 100 mg/kg | 100 mg/kg | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:25275270 | IVTH | 10 - 0.01 mg/L | 0.1 mg/L | Cancer phenotype | Endocrine-mediated cancer |
| PMID:26984284 | IVR | 100 mg/kg | 100 mg/kg | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 20 mg/kg | 20 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:27431321 | IVTH | 0.000000000001 - 0.000000001 M | 0.00000000001 - 0.000000001 M | Affects relaxin-hormone pathway | Metabolic endocrine-mediated perturbations |
| IVTH | 0.000000000001 - 0.000000001 M | 0.00000000001 - 0.000000001 M | Affects uterine function | Reproductive endocrine-mediated perturbations | |
| PMID:28615648 | IVR | 100 mg/kg/day | 100 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations |
| PMID:28847621 | IVR | 200 mg/kg | 200 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:29147981 | IVR | 1 mg/kg | 1 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:29874772 | IVR | 200 mg/kg/day | 200 mg/kg/day | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:30555326 | IVR | 25 mg/kg | 25 mg/kg | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Alterations in number of leydig cells in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:31475654 | IVR | 5 mg/kg/day | 5 mg/kg/day | Hypospadias | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:8829248 | IVR | 150 mg/kg/day | 150 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects ovarian function | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.