Butyl benzyl phthalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:11099647	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Nipple retention	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:11298497	IVTH	0.00000000000001 - 0.00001 M	0.000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.00000000000001 - 0.00001 M	0.000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:11474214	IVR	10 mg	10 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:15883486	IVTH	0.000000001 - 0.001 M	0.000001 - 0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:16326419	IVTH	0.00001 M	0.00001 M	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:16641542	IVR	200 mg/kg/day	200 mg/kg/day	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased spleen weights in offspring	Developmental endocrine-mediated perturbations;Immunological endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects testis development	Developmental e
	IVR	400 mg/kg/day	400 mg/kg/day	Increased weights of thyroid gland in offspring
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased weights of seminal vesicles in offspring
PMID:18062813	IVR	500 mg/kg	500 mg/kg	Affects mammary gland differentiation	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
PMID:21241498	IVR	120 mg/kg/day	120 mg/kg/day	Cancer phenotype	Endocrine-mediated cancer
	IVR	120 mg/kg/day	120 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	120 mg/kg/day	120 mg/kg/day	Affects differentiation process	Developmental endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects differentiation process	Developmental endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Cancer phenotype	Endocrine-mediated cancer
	IVR	500 mg/kg/day	500 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
PMID:21771643	IVTH	0.0000000000001 - 0.000000001 M	0.00001 M	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:25016925	IVTH	0.000000001 - 0.000001 M	0.000000001 - 0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000000001 - 0.000001 M	0.000000001 - 0.000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:26376073	IVR	10 mg/L	10 mg/L	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/L	10 mg/L	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/L	10 mg/L	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:26520405	IVTH	0.000000001 - 0.00005 M	0.000000001 - 0.00005 M	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.00005 M	0.000000001 - 0.00005 M	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:26747412	IVR	500 mg/kg	500 mg/kg	Alters sperm function	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Induce apoptosis of spermatogenic cells	Reproductive endocrine-mediated perturbations
PMID:26895396	IVR	500 mg/kg/day	500 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
PMID:27513369	IVTH	0.000001 - 0.0001 M	0.00001 - 0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.00001 - 0.0001 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.00001 - 0.0001 M	Increase in estradiol/testosterone ratio	Reproductive endocrine-mediated perturbations
PMID:28298639	IVTH	0.000001 M	0.000001 M	Affects myogenic differentiation	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:29250801	IVR	500 mg/kg/day	500 mg/kg/day	Hyperplasia in liver	Hepatic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects estrogen metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:29969652	IVR	250 mg/kg/day	250 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects ovarian function	Reproductive endocrine-mediated perturbations
PMID:30243731	IVTH	0.01 mmol/L	-	No significant effects observed	-
	IVTH	0.00001 mmol/L	-	No significant effects observed	-
	IVTH	0.1 mmol/L	-	No significant effects observed	-
	IVTH	0.001 mmol/L	0.001 mmol/L	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0001 mmol/L	0.0001 mmol/L	Cancer phenotype	Endocrine-mediated cancer
PMID:30851587	IVTH	0.00001 M	0.00001 M	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.