| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:18634860 | IVR | 10 mg/kg/day | 10 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Ovarian carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:21737371 | IVR | 0.001 mg/kg/day | - | No significant effects observed | - |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:22960446 | IVR | 25 mg/kg/day | 25 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | - | No significant effects observed | - | |
| PMID:23037998 | IVR | 10 mg/kg/day | 10 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| PMID:23059060 | IVR | 75 mg/L | - | No significant effects observed | - |
| IVR | 50 mg/L | - | No significant effects observed | - | |
| IVR | 100 mg/L | 100 mg/L | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| PMID:23280776 | IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| PMID:24769007 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| PMID:27221463 | IVR | 0.5 mg/kg | 0.5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Decreased progestagens levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| PMID:28043741 | IVR | 0.2 mg/kg | 0.2 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:28263535 | IVR | 0 NA | - | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| PMID:29649501 | IVR | 150 mg/kg | 150 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| PMID:30443902 | IVR | 0.2 mg/kg | 0.2 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Compromised endometrial receptivity | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Induce apoptosis of endometrial cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000005 M | 0.000005 M | Induce apoptosis of endometrial cells | Reproductive endocrine-mediated perturbations | |
| PMID:31085209 | IVR | 5 mg/kg | 5 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.