Potassium perfluorooctanesulfonate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:18252804	IVR	5 mg/kg/day	5 mg/kg/day	Changes in B-cell populations	Immunological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in haemocrit values	Immunological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Alterations in thymocytes population	Immunological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased liver weights	Hepatic endocrine-mediated perturbations
PMID:24440345	IVR	6 mg/kg/day	6 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased levels of Corticotropin-releasing hormone (CRH)	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased levels of Corticotropin-releasing hormone (CRH)	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:25171141	IVR	3 mg/kg/day	3 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive
	IVR	1 mg/kg/day	1 mg/kg/day	Increased FSH levels
PMID:25623392	IVR	6 mg/kg/day	6 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sexual behavior	Neurological
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels
	IVR	1 mg/kg/day	1 mg/kg/day	Increased serotonin (5-HT) levels
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased estradiol levels
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased LH levels
PMID:26032630	IVR	6 mg/kg	6 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased estrone levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased dopamine levels	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg	3 mg/kg	Decreased estrone levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg	3 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg	3 mg/kg	Decreased dopamine levels	Neurological endocrine-mediated perturbations
PMID:29063134	IVTH	0.0000001 - 0.001 M	0.000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer

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