| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:24893633 | IVR | 6000 mg/kg | 6000 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 6000 mg/kg | 6000 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 6000 mg/kg | 6000 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 6000 mg/kg | 6000 mg/kg | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 6000 mg/kg | 6000 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | - | No significant effects observed | - | |
| IVR | 3000 mg/kg | 3000 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 3000 mg/kg | 3000 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 3000 mg/kg | 3000 mg/kg | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:6122172 | IVR | 4000 mg/kg | 4000 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 4000 mg/kg | 4000 mg/kg | Decreased dopamine levels | Neurological endocrine-mediated perturbations | |
| IVR | 4000 mg/kg | 4000 mg/kg | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 4000 mg/kg | 4000 mg/kg | Affects GABA-receptors | Neurological endocrine-mediated perturbations | |
| PMID:6433129 | IVR | 4000 mg/kg | 4000 mg/kg | Increased thymus gland weights | Immunological endocrine-mediated perturbations |
| IVR | 4000 mg/kg | 4000 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:7920900 | IVR | 2000 mg/kg | 2000 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations |
| IVR | 2000 mg/kg | 2000 mg/kg | Elevated insulin levels | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.