Ammonium perchlorate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:11563414	IVR	3 mg/kg/day	3 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Hyperplasia in liver	Hepatic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Hyperplasia in liver	Hepatic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
PMID:14680992	IVR	30 mg/kg/day	30 mg/kg/day	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Hyperplasia in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Hyperplasia in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	-	No significant effects observed	-
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:17011691	IVR	250 mg/kg	250 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	62.5 mg/kg	62.5 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.