| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12858169 | IVR | 0.0005 mg/kg | 0.0005 mg/kg | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Endometrial carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Increased weights of endometrium | Reproductive endocrine-mediated perturbations | |
| PMID:19636671 | IVR | 25 mg/L | 25 mg/L | Affects the biochemical composition of pituitary gland | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 50 mg/L | 50 mg/L | Affects the biochemical composition of pituitary gland | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:19703529 | IVR | 0.00005 - 9 mg/kg | 9 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 0.00005 - 9 mg/kg | 0.05 - 2 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.00005 - 9 mg/kg | 0.5 - 2 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:20186393 | IVR | 0.00005 - 9 mg/kg | 9 mg/kg | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations |
| PMID:20197112 | IVTH | 0.00000000001 - 0.0000001 M | 0.00000000001 - 0.0000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| PMID:20525538 | IVR | 0.05 mg/kg | 0.05 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:20580663 | IVTH | 0.00001 M | 0.00001 M | Affects differentiation process | Developmental endocrine-mediated perturbations |
| IVTH | 0.000001 M | - | No significant effects observed | - | |
| IVTH | 0.0000001 M | 0.0000001 M | Affects differentiation process | Developmental endocrine-mediated perturbations | |
| IVTH | 0.0000001 M | 0.0000001 M | Oxidative stress in placenta | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 M | 0.00000001 M | Affects differentiation process | Developmental endocrine-mediated perturbations | |
| IVTH | 0.00000001 M | 0.00000001 M | Affects endometrial angiogenesis | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:23358149 | IVR | 4.5 mg/kg | 4.5 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 4.5 mg/kg | 4.5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 4.5 mg/kg | 4.5 mg/kg | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 6 mg/kg | 6 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 6 mg/kg | 6 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 6 mg/kg | 6 mg/kg | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:24015267 | IVTH | 0.0000001 M | 0.0000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.0000001 M | 0.0000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer | |
| PMID:25723060 | IVTH | 0.0000078 M | 0.0000078 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000312 M | 0.0000312 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000312 M | 0.0000312 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000156 M | 0.0000156 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000625 M | 0.0000625 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000625 M | 0.0000625 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000019 M | - | No significant effects observed | - | |
| IVTH | 0.0000039 M | - | No significant effects observed | - | |
| PMID:26558472 | IVR | 0.1 mg/L | 0.1 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 0.01 mg/L | 0.01 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:29574358 | IVR | 5 mg/kg | 5 mg/kg | Increased progesterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Increased ovarian weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased uterine weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased estradiol levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Endometrial hyperplasia in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Alterations in endometrial morphology in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects ovarian follicles population in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects steroidogenesis in offspring | D | |
| PMID:30066076 | IVR | 4.5 mg/kg/day | 4.5 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 4.5 mg/kg/day | 4.5 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 4.5 mg/kg/day | 4.5 mg/kg/day | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 4.5 mg/kg/day | 4.5 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 4.5 mg/kg/day | 4.5 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 4.5 mg/kg/day | 4.5 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.09 mg/kg/day | 0.09 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.09 mg/kg/day | 0.09 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.8 mg/kg/day | 1.8 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1.8 mg/kg/day | 1.8 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:30278395 | IVR | 10 mg/L | 10 mg/L | Affects GABA-receptors | Neurological endocrine-mediated perturbations |
| IVR | 10 mg/L | 10 mg/L | Abnormal neuronal distribution in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:30478740 | IVTH | 0.00001 M | 0.00001 M | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects cytokine signaling | Immunological endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects androgen signaling | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000005 M | 0.000005 M | Affects cytokine signaling | Immunological endocrine-mediated perturbations | |
| IVTH | 0.000005 M | 0.000005 M | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.000005 M | 0.000005 M | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000005 M | 0.000005 M | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| PMID:30590866 | IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| PMID:31014900 | IVR | 5 mg/kg/day | 5 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:31899225 | IVR | 5 mg/kg | 5 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased Aspartate aminotransferase (AST) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Reduced glutathione levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.