| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:14691014 | IVTH | 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:15371226 | IVR | 200 mg | 200 mg | Affects uterine development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 200 mg | 200 mg | Affects development of seminal vesicles | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg | 200 mg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg | 25 mg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 800 mg | - | No significant effects observed | - | |
| IVR | 100 mg | 100 mg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg | 100 mg | Azoospermic | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg | 100 mg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 675 mg | 675 mg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 675 mg | 675 mg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 675 mg | 675 mg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg | 400 mg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg | 50 mg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg | 50 mg | Azoospermic | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg | 50 mg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:2501910 | IVR | 200 mg/kg | 200 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg | 400 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:26071454 | IVR | 100 mg/kg | 100 mg/kg | Affects lipid metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 500 mg/kg | 500 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:30496565 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| PMID:9242589 | IVR | 164 mg/kg | 164 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations |
| IVR | 164 mg/kg | 164 mg/kg | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.