| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:20020863 | IVR | 5000 mg/kg/day | 5000 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 1250 mg/kg/day | 1250 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1250 mg/kg/day | 1250 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1250 mg/kg/day | 1250 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1250 mg/kg/day | 1250 mg/kg/day | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 1250 mg/kg/day | 1250 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 2500 mg/kg/day | 2500 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 625 mg/kg/day | 625 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 625 mg/kg/day | 625 mg/kg/day | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 625 mg/kg/day | 625 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 625 mg/kg/day | 625 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 625 mg/kg/day | 625 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.