| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:1506076 | IVR | 20 mg/kg | 20 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations |
| IVR | 40 mg/kg | 40 mg/kg | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 40 mg/kg | 40 mg/kg | Decreased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | - | No significant effects observed | - | |
| IVR | 10 mg/kg | - | No significant effects observed | - | |
| PMID:20131380 | IVR | 25 mg/kg | 25 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg | 25 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:21397294 | IVR | 20 mg/kg | 20 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg | 20 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | - | No significant effects observed | - | |
| PMID:24440342 | IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| PMID:24641848 | IVR | 80 mg/kg | 80 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 80 mg/kg | 80 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:24810582 | IVR | 0.12 mg/kg/day | 0.12 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 0.12 mg/kg/day | 0.12 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1.2 mg/kg/day | 1.2 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1.2 mg/kg/day | 1.2 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1.2 mg/kg/day | 1.2 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.2 mg/kg/day | 1.2 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| PMID:24916741 | IVR | 10 mg/kg | 10 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:26877835 | IVTH | 0.00001 M | 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:28709042 | IVR | 25 mg/kg/day | 25 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | - | No significant effects observed | - | |
| PMID:28731686 | IVR | 0.05 mg/kg | 0.05 mg/kg | Alters hypothalamic-pituitary-gonadal axis (HPG axis) | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Accelerated onset of puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg | 0.05 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Accelerated onset of puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg | 0.0005 mg/kg | Alters hypothalamic-pituitary-gonadal axis (HPG axis) | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Alters hypothalamic-pituitary-gonadal axis (HPG axis) | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Accelerated onset of puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Increased testosterone levels | Reproductive | |
| PMID:29253587 | IVR | 20 mg/kg/day | 20 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| PMID:31863984 | IVR | 25 mg/kg/day | 25 mg/kg/day | Affects fertility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased uterine weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased weights of adrenal gland in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects uterine morphology in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased ovarian weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects implantation in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects fertility in offspring | Deve | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects implantation in offspring | ||
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased testosterone levels in offspring | ||
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased progesterone levels in offspring | ||
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects folliculogenesis in offspring |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.