N,N'-Methylene-bis(2-amino-5-sulfhydryl-1,3,4-thiadiazole)


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:19070471IVR20 mg/kg/day 20 mg/kg/dayHyperplasia in thyroid glandMetabolic endocrine-mediated perturbations
IVR20 mg/kg/day 20 mg/kg/dayHypertrophy in thyroid glandMetabolic endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayIncreased ovarian weightsReproductive endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayDecrease in T3 levelsMetabolic endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayHyperplasia in thyroid glandMetabolic endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayIncrease in TSH levelsMetabolic endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayIncreased weights of thyroid glandMetabolic endocrine-mediated perturbations
IVR40 mg/kg/day 40 mg/kg/dayHypertrophy in thyroid glandMetabolic endocrine-mediated perturbations
IVR10 mg/kg/day 10 mg/kg/dayHyperplasia in thyroid glandMetabolic endocrine-mediated perturbations
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.