Fenvalerate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10064545	IVTH	0.0000000001 - 0.001 M	0.000001 - 0.00001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.0000000001 - 0.001 M	0.000001 - 0.00001 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:15363582	IVTH	0.000001 M	-	No significant effects observed	-
	IVTH	0.000125 M	0.000125 M	Affects calcium signaling in ovary	Reproductive endocrine-mediated perturbations
	IVTH	0.000125 M	0.000125 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000025 M	0.000025 M	Affects calcium signaling in ovary	Reproductive endocrine-mediated perturbations
	IVTH	0.000025 M	0.000025 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Affects calcium signaling in ovary	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:16005607	IVR	10 mg/kg	10 mg/kg	Altered lordosis	Developmental endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
PMID:16673813	IVR	9.55 mg/kg	-	No significant effects observed	-
	IVR	31.8 mg/kg	31.8 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	31.8 mg/kg	31.8 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	31.8 mg/kg	31.8 mg/kg	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	1.91 mg/kg	1.91 mg/kg	Affects neuronal differentiation	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:19727571	IVR	100 mg/kg/day	100 mg/kg/day	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
PMID:20063364	IVR	60 mg/kg	60 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:20230880	IVTH	0.01 - 100 M	0.1 - 100 M	Uterine carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVTH	0.01 - 100 M	10 - 100 M	Uterine carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:21232584	IVR	30 mg/kg	30 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	7.5 mg/kg	7.5 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	7.5 mg/kg	7.5 mg/kg	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	7.5 mg/kg	7.5 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:21458547	IVR	30 mg/kg/day	30 mg/kg/day	Affects spatial memory	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects spatial learning	Neurological endocrine-mediated perturbations
	IVR	7.5 mg/kg/day	7.5 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	7.5 mg/kg/day	7.5 mg/kg/day	Affects spatial learning	Neurological endocrine-mediated perturbations
	IVR	7.5 mg/kg/day	7.5 mg/kg/day	Affects spatial memory	Neurological endocrine-mediated perturbations
PMID:28369636	IVR	0.2 mg/kg	-	No significant effects observed	-
	IVR	20 mg/kg	20 mg/kg	Affects expression of thyroid receptor (TR)	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects uterine development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.