2,3',4,4',5-Pentachlorobiphenyl

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
DOI:10.1093/icb/37.4.399	IVR	16 mg/kg	16 mg/kg	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	16 mg/kg	16 mg/kg	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	4 mg/kg	4 mg/kg	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	4 mg/kg	4 mg/kg	Increase in T4 levels	Metabolic endocrine-mediated perturbations
PMID:12642156	IVTH	0.01 - 20 mg/L	0.1 - 20 mg/L	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.01 - 20 mg/L	20 mg/L	Affects androgen signaling	Reproductive endocrine-mediated perturbations
PMID:20574914	IVTH	0.00000000001 - 0.000004 M	0.000004 M	Increased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00000000001 - 0.000004 M	0.000004 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000000001 - 0.000004 M	0.000004 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000000001 - 0.000004 M	0.000004 M	Increase in cortisol levels	Neurological endocrine-mediated perturbations
PMID:23557935	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	0.01 mg/kg/day	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects iodine uptake into thyroid	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects iodine uptake into thyroid	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
PMID:24754389	IVTH	0.0000141 M	0.0000141 M	Increase in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000141 M	0.0000141 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000004 M	0.000004 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000004 M	0.000004 M	Increase in cortisol levels	Neurological endocrine-mediated perturbations
PMID:28631552	IVR	0.01 mg/kg	0.01 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg	0.01 mg/kg	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg	0.01 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg	0.001 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg	0.001 mg/kg	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg	0.001 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
PMID:8516785	IVR	16 mg/kg/day	16 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	16 mg/kg/day	16 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	4 mg/kg/day	4 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	4 mg/kg/day	4 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations

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