2,2',4,4',5-Pentabromodiphenyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15687051	IVR	0.06 mg/kg	0.06 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.06 mg/kg	0.06 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.06 mg/kg	0.06 mg/kg	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
PMID:16451854	IVR	10 mg/kg	10 mg/kg	Decreased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decreased weights of pituitary gland in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Delayed puberty in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:17964054	IVR	0.06 mg/kg	0.06 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:20488217	IVR	0.6 mg/kg	0.6 mg/kg	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Increased Lactate dehydrogenase (LDH) levels	Metabolic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Increased Lactate dehydrogenase (LDH) levels	Metabolic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:21783486	IVR	452 mg/kg	452 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	452 mg/kg	452 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations

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