| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12533912 | IVR | 1000 mg/kg | 1000 mg/kg | Affects iodine uptake into thyroid | Metabolic endocrine-mediated perturbations |
| IVR | 1000 mg/kg | 1000 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:19483384 | IVR | 2 % | 2 % | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations |
| IVR | 2 % | 2 % | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Increased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Thyroid gland carcinoma | Endocrine-mediated cancer;Metabolic endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 % | 0.5 % | Affects morphology of hepatocytes | Hepatic endocrine-mediated perturbations | |
| IVR | 0.5 % | 0.5 % | Increased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 0.5 % | 0.5 % | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 0.5 % | 0.5 % | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:9734720 | IVR | 2 % | 2 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 2 % | 2 % | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 % | 3 % | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 % | 3 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 3 % | 3 % | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1.5 % | 1.5 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 80 % | 80 % | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 % | 80 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 80 % | 80 % | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 8 % | 8 % | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 8 % | 8 % | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 8 % | 8 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.