Vinclozolin

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10641015	IVR	100 mg/kg	100 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
PMID:11029267	IVR	3 mg/kg	-	No significant effects observed	-
	IVR	6 mg/kg	-	No significant effects observed	-
	IVR	1 mg/kg	-	No significant effects observed	-
	IVR	200 mg/kg	200 mg/kg	Changes in morphology of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Nipple retention	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Changes in number of nipples	Reproductive endocrine-mediated perturbations
PMID:12060841	IVR	200 mg/kg	200 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:12127262	IVTH	0.0001 M	0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:14613717	IVR	250 mg/kg/day	250 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:14966743	IVR	200 mg/kg/day	200 mg/kg/day	Affects testis development in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects locomotor activity	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Alteration in vaginal morphology	Reproductive endocrine-mediated perturbations
PMID:15279874	IVR	100 mg/kg/day	100 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
PMID:15929892	IVR	6 mg/kg	6 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg	3 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1.5 mg/kg	1.5 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:15933200	IVR	100 - 200 mg/kg	100 - 200 mg/kg	Induce apoptosis of spermatogenic cells	Reproductive endocrine-mediated perturbations
	IVR	100 - 200 mg/kg	100 - 200 mg/kg	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 - 200 mg/kg	100 - 200 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 - 200 mg/kg	100 - 200 mg/kg	Affects spermatogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 - 200 mg/kg	100 - 200 mg/kg	Affects fertility	Reproductive endocrine-mediated perturbations
PMID:16641540	IVR	3000 mg/kg/day	-	No significant effects observed	-
	IVR	500 mg/kg/day	-	No significant effects observed	-
	IVR	6000 mg/kg/day	-	No significant effects observed	-
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased prostate weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased ovarian weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Hyperplasia in testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of pituitary gland in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of epididymis	Reproductive endocrin
	IVR	1000 mg/kg/day	1000 mg/kg/day	Hyperplasia in ovary
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of seminal vesicles in offspring
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased brain weights in offspring
	IVR	1000 mg/kg/day	1000 mg/kg/day	Atrophy of seminal vesicles
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased testis weights
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased liver weights
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of adrenal gland in offspring
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased testis weights in offspring
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased prostate weights in offspring
	IVR	200 mg/kg/day	200 mg/kg/day	Alterations in prepu
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	200 mg/kg/day	200 mg/kg/day
	IVR	40 mg/kg/day	40 mg/kg/day
	IVR	40 mg/kg/day	40 mg/kg/day
	IVR	40 mg/kg/day	40 mg/kg/day
PMID:16837734	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Induce apoptosis of spermatogenic cells	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
PMID:16962624	IVTH	0.000001 - 0.0003 M	0.00003 - 0.0001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0003 M	0.00003 - 0.0001 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0003 M	0.00003 - 0.0001 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:16973726	IVR	100 mg/kg/day	100 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects testicular function	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Induce apoptosis of spermatogenic cells	Reproductive endocrine-mediated perturbations
PMID:17905137	IVR	10 mg/kg/day	10 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
PMID:18042343	IVR	100 mg/kg/day	100 mg/kg/day	Affects testicular function	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
PMID:18220299	IVR	100 mg/kg/day	100 mg/kg/day	Affects prostate function	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Cancer phenotype	Endocrine-mediated cancer
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects Wnt signaling pathway	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
PMID:18304984	IVR	100 mg/kg/day	100 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in morphology of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:18629315	IVR	100 mg/kg	100 mg/kg	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Induce cancer metastasis	Endocrine-mediated cancer
	IVR	100 mg/kg	100 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
PMID:18940246	IVR	1 mg/kg	1 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
PMID:19672408	IVR	1 mg/kg/day	1 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
PMID:19887539	IVR	50 mg/kg/day	50 mg/kg/day	Epigenomic alterations in sperm	Reproductive endocrine-mediated perturbations
PMID:20056826	IVR	100 mg/kg	100 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Prostate hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
PMID:20566332	IVR	100 mg/kg	100 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
PMID:20616205	IVR	30 mg/kg	30 mg/kg	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Alters sperm function	Reproductive endocrine-mediated perturbations
PMID:20927350	IVR	100 mg/kg/day	100 mg/kg/day	Epigenomic alterations in sperm	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:21172421	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects gametogenesis	Reproductive endocrine-mediated perturbations
PMID:21636974	IVR	100 mg/kg/day	100 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:22285353	IVR	100 mg/kg	100 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased estrone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased LH levels	Reproductive endocrine-mediated perturbations
PMID:23041264	IVR	100 mg/kg/day	100 mg/kg/day	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Changes in ovarian morphology of offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
PMID:23160963	IVR	1 mg/kg/day	1 mg/kg/day	Affects carbohydrates metabolism	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:25051444	IVR	100 mg/kg/day	100 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:25324206	IVTH	0.00003 M	0.00003 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00003 M	0.00003 M	Affects androgen signaling	Reproductive endocrine-mediated perturbations
	IVTH	0.0000003 M	-	No significant effects observed	-
	IVTH	0.000003 M	0.000003 M	Affects androgen signaling	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Affects androgen signaling	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00001 M	0.00001 M	Affects androgen signaling	Reproductive endocrine-mediated perturbations
PMID:25784924	IVR	100 mg/kg	100 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:25853433	IVR	100 mg/kg/day	100 mg/kg/day	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:25897752	IVR	1 mg/kg	1 mg/kg	Affects differentiation process	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects differentiation process	Developmental endocrine-mediated perturbations
PMID:25929820	IVR	150 mg/kg/day	150 mg/kg/day	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Increase in estradiol/testosterone ratio	Reproductive endocrine-mediated perturbations
PMID:27684650	IVTH	0.00000001 - 0.000001 M	0.00000001 - 0.000001 M	Affects developmental process	Developmental endocrine-mediated perturbations
PMID:27992467	IVR	100 mg/kg/day	100 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
PMID:29668838	IVR	300 mg/kg	300 mg/kg	Hypospadias	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg	150 mg/kg	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg	150 mg/kg	Hypospadias	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Hypospadias	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	75 mg/kg	75 mg/kg	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	75 mg/kg	75 mg/kg	Hypospadias	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg	600 mg/kg	Hypospadias	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Hypospadias	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Affects penis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:30212226	IVR	1 mg/kg	1 mg/kg	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:30444163	IVR	1 mg/kg	1 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Alters sperm function	Reproductive endocrine-mediated perturbations
PMID:31491443	IVR	1 mg/kg	1 mg/kg	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
PMID:7974495	IVR	100 mg/kg/day	100 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects development of reproductive system	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects development of reproductive system	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
PMID:9007049	IVR	200 mg/kg/day	200 mg/kg/day	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased weights of seminal vesicles	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.