| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12473415 | IVR | 2 mg/kg | 2 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | - | No significant effects observed | - | |
| IVR | 4 mg/kg | 4 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| PMID:17683461 | IVR | 1 mg/kg | 1 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| PMID:27164926 | IVR | 5 mg/kg | 5 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decreased inhibin-B levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.