Miconazole

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:20708073	IVTH	0.0000001 - 0.00003 M	0.0000003 - 0.00003 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:31330226	IVTH	0.0000000031 M	-	No significant effects observed	-
	IVTH	0.00000001 M	-	No significant effects observed	-
	IVTH	0.000000001 M	-	No significant effects observed	-
	IVTH	0.0000000314 M	0.0000000314 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000314 M	0.0000000314 M	Increased 17-OH-pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000314 M	0.0000000314 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000314 M	0.0000000314 M	Increased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000314 M	0.0000000314 M	Increased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.0000000314 M	0.0000000314 M	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000000314 M	0.0000000314 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased 17-OH-pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Decreased estrone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000207 M	0.000000207 M	Increased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000207 M	0.000000207 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000207 M	0.000000207 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000207 M	0.000000207 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.000000207 M	0.000000207 M	Increase in corticosterone levels	Neurological en
	IVTH	0.000000207 M	0.000000207 M	Increased 17-OH-pregnenolone levels
	IVTH	0.000000207 M	0.000000207 M	Increased 17-OH-progesterone levels
	IVTH	0.00001 M	0.00001 M	Increase in corticosterone levels
	IVTH	0.00001 M	0.00001 M	Decreased estradiol levels
	IVTH	0.00001 M	0.00001 M	Affects steroid metabolism
	IVTH	0.00001 M	0.00001 M	Increased 17-OH-progesterone levels
	IVTH	0.00001 M	0.00001 M	Decreased estrone levels
	IVTH	0.00001 M	0.00001 M	Increased pregnenolone levels
	IVTH	0.00001 M	0.00001 M	Increased progesterone levels
	IVTH	0.00001 M	0.00001 M	Increased 17-OH-pregnenolone level
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.000000314 M	0.000000314 M
	IVTH	0.0000001 M	0.0000001 M
	IVTH	0.0000001 M	0.0000001 M
	IVTH	0.0000001 M	0.0000001 M
	IVTH	0.0000001 M	0.0000001 M
	IVTH	0.0000001 M	0.0000001 M
	IVTH	0.0000001 M	0.0000001 M
	IVTH	0.0000001 M	0.0000001 M

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.