Cyanoginosin LR

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:25375936	IVR	0.03 mg/kg/day	0.03 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.03 mg/kg/day	0.03 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.03 mg/kg/day	0.03 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.03 mg/kg/day	0.03 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.00375 mg/kg/day	-	No significant effects observed	-
	IVR	0.0075 mg/kg/day	0.0075 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.0075 mg/kg/day	0.0075 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0075 mg/kg/day	0.0075 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.0075 mg/kg/day	0.0075 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.015 mg/kg/day	0.015 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.015 mg/kg/day	0.015 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.015 mg/kg/day	0.015 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.015 mg/kg/day	0.015 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
PMID:25497113	IVR	0.02 mg/kg	0.02 mg/kg	Decreased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Reduced glucose levels	Metabolic endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Cancer phenotype	Endocrine-mediated cancer
	IVR	0.02 mg/kg	0.02 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Affects cholesterol metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
PMID:27608041	IVR	0.03 mg/kg	0.03 mg/kg	Cancer phenotype	Endocrine-mediated cancer
	IVR	0.0075 mg/kg	0.0075 mg/kg	Cancer phenotype	Endocrine-mediated cancer
	IVR	0.015 mg/kg	0.015 mg/kg	Cancer phenotype	Endocrine-mediated cancer
PMID:29772511	IVTH	1000 mg/L	1000 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	10000 mg/L	10000 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	10000 mg/L	10000 mg/L	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	100000 mg/L	100000 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	500000 mg/L	500000 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	500000 mg/L	500000 mg/L	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	1000000 mg/L	1000000 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	1000000 mg/L	1000000 mg/L	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	5000000 mg/L	5000000 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	5000000 mg/L	5000000 mg/L	Decreased estradiol levels	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.