Benzophenone-3


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:11333184IVR937 mg/kg/day -No significant effects observed-
IVR611 mg/kg/day -No significant effects observed-
IVR1525 mg/kg/day 1525 mg/kg/dayIncreased uterine weightsReproductive endocrine-mediated perturbations
IVTH0.00001 M 0.00001 MOccurrence of mammary gland tumorEndocrine-mediated cancer;Reproductive endocrine-mediated perturbations
IVTH0.0000001 - 0.00005 M 0.000005 - 0.00005 MCancer phenotypeEndocrine-mediated cancer
PMID:15458797IVR250 mg/kg 250 mg/kgAffects expression of estrogen receptor-alpha (ER-alpha)Reproductive endocrine-mediated perturbations
IVR250 mg/kg 250 mg/kgIncreased uterine weightsReproductive endocrine-mediated perturbations
IVR250 mg/kg 250 mg/kgAffects expression of estrogen receptor-beta (ER-beta)Reproductive endocrine-mediated perturbations
IVR1000 mg/kg 1000 mg/kgIncreased uterine weightsReproductive endocrine-mediated perturbations
IVR1000 mg/kg 1000 mg/kgAffects the normal functioning of reproductive systemReproductive endocrine-mediated perturbations
IVR1000 mg/kg 1000 mg/kgAffects xenobiotic metabolismMetabolic endocrine-mediated perturbations
PMID:28990245IVTH0.00001 M 0.00001 MInduced migration capability of tumor cellsEndocrine-mediated cancer
IVTH0.0000001 M 0.0000001 MInduced migration capability of tumor cellsEndocrine-mediated cancer
PMID:30057971IVR0.212 mg/kg/day 0.212 mg/kg/dayAffects expression of estrogen receptor (ER)Reproductive endocrine-mediated perturbations
IVR0.212 mg/kg/day 0.212 mg/kg/dayAffects expression of progesterone receptor (PR)Reproductive endocrine-mediated perturbations
IVR0.212 mg/kg/day 0.212 mg/kg/dayInduce tumor progressionEndocrine-mediated cancer
IVR0.03 mg/kg/day 0.03 mg/kg/dayAffects expression of estrogen receptor (ER)Reproductive endocrine-mediated perturbations
IVR0.03 mg/kg/day 0.03 mg/kg/dayInduce tumor progressionEndocrine-mediated cancer
IVR3 mg/kg/day 3 mg/kg/dayAffects expression of progesterone receptor (PR)Reproductive endocrine-mediated perturbations
IVR3 mg/kg/day 3 mg/kg/dayAffects expression of estrogen receptor (ER)Reproductive endocrine-mediated perturbations
IVR3 mg/kg/day 3 mg/kg/dayAffects expression of estrogen receptor-alpha (ER-alpha)Reproductive endocrine-mediated perturbations
IVR3 mg/kg/day 3 mg/kg/dayInduce tumor progressionEndocrine-mediated cancer
PMID:31408669IVR0.212 mg/kg/day 0.212 mg/kg/dayAffects expression of estrogen receptor-alpha (ER-alpha) in offspringDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.212 mg/kg/day 0.212 mg/kg/dayAffects anogenital distance in offspringDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.03 mg/kg/day 0.03 mg/kg/dayChanges in mammary gland morphology in offspringDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.03 mg/kg/day 0.03 mg/kg/dayAffects expression of estrogen receptor-alpha (ER-alpha) in offspringDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.03 mg/kg/day 0.03 mg/kg/dayAlters mammary gland developmentDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR3 mg/kg/day 3 mg/kg/dayAlters mammary gland developmentDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR3 mg/kg/day 3 mg/kg/dayChanges in mammary gland morphology in offspringDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.