Daidzein


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:17673432IVR100 mg/kg 100 mg/kgErectile dysfunctionReproductive endocrine-mediated perturbations
IVR100 mg/kg 100 mg/kgAffects sexual behaviorNeurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR100 mg/kg 100 mg/kgDecreased testosterone levelsReproductive endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgErectile dysfunctionReproductive endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgDecreased testosterone levelsReproductive endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgAffects sexual behaviorNeurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR2 mg/kg -No significant effects observed-
PMID:20732377IVTH0.00000001 - 0.00001 M 0.0000001 - 0.00001 MDecreased aldosterone levelsMetabolic endocrine-mediated perturbations
IVTH0.00000001 - 0.00001 M 0.0000001 - 0.00001 MDecrease in cortisol levelsNeurological endocrine-mediated perturbations
IVTH0.00000001 - 0.00001 M 0.0000001 - 0.00001 MDecreased testosterone levelsReproductive endocrine-mediated perturbations
PMID:28396216IVTH0.00000000001 - 0.00001 M 0.000001 - 0.00001 MCancer phenotypeEndocrine-mediated cancer
PMID:29338944IVR30 mg/kg 30 mg/kgDecreased testosterone levelsReproductive endocrine-mediated perturbations
IVR30 mg/kg 30 mg/kgIncreased levels of adrenocortical hormones (ACTH)Metabolic endocrine-mediated perturbations
IVR30 mg/kg 30 mg/kgDecreased levels of adrenocortical hormones (ACTH)Metabolic endocrine-mediated perturbations
PMID:31371049IVTH0.0001 M 0.0001 MAffects endometrial developmentDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVTH0.00005 M 0.00005 MAffects endometrial developmentDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVTH0.00001 M -No significant effects observed-
PMID:31533020IVR5 mg/kg/day 5 mg/kg/dayAffects uterine morphologyReproductive endocrine-mediated perturbations
IVR5 mg/kg/day 5 mg/kg/dayIncreased uterine weightsReproductive endocrine-mediated perturbations
IVR5 mg/kg/day 5 mg/kg/dayAlteration in vaginal morphologyReproductive endocrine-mediated perturbations
IVR5 mg/kg/day 5 mg/kg/dayIncreased weights of vaginaReproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.