Triphenyltin

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:11097870	IVTH	0.000000001 M	0.000000001 M	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 M	0.000000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0000000003 M	-	No significant effects observed	-
	IVTH	0.0000000001 M	-	No significant effects observed	-
PMID:12050258	IVTH	0.000000001 - 0.00001 M	0.00000001 - 0.00000003 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.00001 M	0.0000001 - 0.00000003 M	Increased hCG levels	Reproductive endocrine-mediated perturbations
PMID:15337578	IVR	2 mg/kg	2 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	12 mg/kg	12 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
PMID:16464526	IVR	2 mg/kg	2 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased brain weights	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Increased ovarian weights	Reproductive endocrine-mediated perturbations
PMID:20563930	IVR	3.75 mg/kg	-	No significant effects observed	-
	IVR	1.88 mg/kg	-	No significant effects observed	-
	IVR	7.5 mg/kg	7.5 mg/kg	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	7.5 mg/kg	7.5 mg/kg	Changes in liver morphology	Hepatic endocrine-mediated perturbations
PMID:25465476	IVTH	0.000000001 - 0.0000001 M	0.00000001 - 0.0000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0000001 M	0.00000001 - 0.0000001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0000001 M	0.00000001 - 0.0000001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:29549738	IVTH	0.0000001 M	0.0000001 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00000005 M	0.00000005 M	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00000005 M	0.00000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 M	0.00000005 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 M	-	No significant effects observed	-
PMID:30772500	IVR	2 mg/kg/day	2 mg/kg/day	Alterations in number of leydig cells in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects sertoli cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects testis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Alterations in number of leydig cells in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sertoli cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects testis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Re
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects steroidogenesis
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects testis development

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.