Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
---|---|---|---|---|---|
PMID:17474020 | IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased liver weights in offspring | Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations |
IVR | 15 mg/kg/day | 15 mg/kg/day | Increased prostate weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased brain weights | Neurological endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased spleen weights in offspring | Developmental endocrine-mediated perturbations;Immunological endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased brain weights in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Increased weights of adrenal gland in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
IVR | 15 mg/kg/day | 15 mg/kg/day | Decreased weights of seminal vesicles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
IVR | 30 mg/kg/day | 30 mg/kg/day | Increased prostate weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased brain weights | Neurological endocrine-mediated perturbations | |
IVR | 30 mg/kg/day | 30 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased brain weights in offspring | Developmental en | |
IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Increased prostate weights in offspring | ||
IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased spleen weights in offspring | ||
IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Decreased spleen weights in offspring | ||
IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased liver weights | ||
IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Decreased brain weights | ||
IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased spleen weights | ||
IVR | 7.5 mg/kg/day | 7.5 mg/kg/day | Decreased liver weights |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.