| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:15147785 | IVR | 9.4 mg/kg | 9.4 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 300 mg/kg | 300 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 37.5 mg/kg | 37.5 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg | 75 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 18.8 mg/kg | 18.8 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.8 mg/kg | - | No significant effects observed | - | |
| IVR | 4 mg/kg | 4 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000001 - 0.00001 M | 0.000006 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:15458796 | IVR | 0.24 mg/kg/day | 0.24 mg/kg/day | Delayed puberty | Reproductive endocrine-mediated perturbations |
| IVR | 0.24 mg/kg/day | 0.24 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 2.4 mg/kg/day | 2.4 mg/kg/day | Decreased weights of epididymis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.7 mg/kg/day | - | No significant effects observed | - | |
| PMID:19150460 | IVR | 7 mg/kg/day | 7 mg/kg/day | Affects expression of estrogen receptor (ER) | Reproductive endocrine-mediated perturbations |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2.4 mg/kg/day | 2.4 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2.4 mg/kg/day | 2.4 mg/kg/day | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 2.4 mg/kg/day | 2.4 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.7 mg/kg/day | - | No significant effects observed | - | |
| IVR | 0.24 mg/kg/day | - | No significant effects observed | - | |
| PMID:24004914 | IVTH | 0.00000001 - 0.00001 M | 0.000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:30189007 | IVTH | 0.00000039 - 0.0002 M | 0.00000039 - 0.0002 M | Alters sperm function | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.