Di-(5-methylhexyl)phthalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:16249068	IVR	4500 mg/L	4500 mg/L	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	4500 mg/L	4500 mg/L	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	4500 mg/L	4500 mg/L	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg	750 mg/kg	Anophthalmia	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg	750 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg	750 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg	750 mg/kg	Affects testis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg	750 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg	750 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	8000 mg/L	8000 mg/L	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	8000 mg/L	8000 mg/L	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	8000 mg/L	8000 mg/L	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	1000 mg/L	-	No significant effects observed	-
PMID:21633115	IVR	300 mg/kg/day	300 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	900 mg/kg/day	900 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	-	No significant effects observed	-

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