| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:11248141 | IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.4 mg/kg/day | - | No significant effects observed | - | |
| PMID:15646809 | IVR | 7 mg/kg | 7 mg/kg | Increased levels of adrenocortical hormones (ACTH) | Metabolic endocrine-mediated perturbations |
| PMID:16289407 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased cowper's gland weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased weights of penis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Increased weights of bulbocavernosus muscles/LABC | Reproductive endocrine-mediated perturbations | |
| PMID:17218470 | IVR | 1.5 mg/kg | 1.5 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations |
| IVR | 1.5 mg/kg | 1.5 mg/kg | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1.5 mg/kg | 1.5 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 1.5 mg/kg | 1.5 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Changes in number of nipples | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 mg/kg | 2.5 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| PMID:17574608 | IVR | 10 mg/kg | 10 mg/kg | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations |
| PMID:19241440 | IVR | 0.4 mg/kg | - | No significant effects observed | - |
| PMID:24239981 | IVR | 10000 mg/L | 10000 mg/L | Exhibit sexual dimorphism | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 10000 mg/L | 10000 mg/L | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 10000 mg/L | 10000 mg/L | Affects liver function | Hepatic endocrine-mediated perturbations | |
| PMID:24617542 | IVR | 0.1 mg/kg | 0.1 mg/kg | Altered lordosis | Developmental endocrine-mediated perturbations |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Altered lordosis | Developmental endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg | - | No significant effects observed | - |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.