| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10627660 | IVR | 100 mg/kg | 100 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:19187594 | IVR | 6 mg/kg/day | 6 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 6 mg/kg/day | 6 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/kg/day | - | No significant effects observed | - | |
| IVR | 1 mg/kg/day | - | No significant effects observed | - | |
| PMID:23146592 | IVR | 0.25 mg/L | 0.25 mg/L | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations |
| IVR | 1.25 mg/L | 1.25 mg/L | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.25 mg/L | 1.25 mg/L | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.