Carbon disulfide


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:10627660IVR100 mg/kg 100 mg/kgReduced sperm countsReproductive endocrine-mediated perturbations
IVR50 mg/kg 50 mg/kgIncreased weights of adrenal glandMetabolic endocrine-mediated perturbations
IVR50 mg/kg 50 mg/kgReduced sperm countsReproductive endocrine-mediated perturbations
IVR200 mg/kg 200 mg/kgReduced sperm countsReproductive endocrine-mediated perturbations
IVR25 mg/kg 25 mg/kgIncreased weights of adrenal glandMetabolic endocrine-mediated perturbations
IVR25 mg/kg 25 mg/kgReduced sperm countsReproductive endocrine-mediated perturbations
PMID:19187594IVR6 mg/kg/day 6 mg/kg/dayChanges in morphology of thyroid glandMetabolic endocrine-mediated perturbations
IVR6 mg/kg/day 6 mg/kg/dayDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR3 mg/kg/day -No significant effects observed-
IVR1 mg/kg/day -No significant effects observed-
PMID:23146592IVR0.25 mg/L 0.25 mg/LIncrease in the number of abnormal spermsReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LAffects neuronal signalingNeurological endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LAffects sperm motilityReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LDecreased testosterone levelsReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LReduced sperm countsReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LIncreased FSH levelsReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LDecreased LH levelsReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LDecreased FSH levelsReproductive endocrine-mediated perturbations
IVR1.25 mg/L 1.25 mg/LIncrease in the number of abnormal spermsReproductive endocrine-mediated perturbations
IVR0.05 mg/L 0.05 mg/LIncrease in the number of abnormal spermsReproductive endocrine-mediated perturbations
IVR0.05 mg/L 0.05 mg/LAffects neuronal signalingNeurological endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.