1,2-Propylene oxide

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:12748685	IVR	400 mg/L	400 mg/L	Changes in morphology of pancreas	Metabolic endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Endometrial hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Thyroid gland carcinoma	Endocrine-mediated cancer;Metabolic endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Endometrial carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Changes in adrenal gland morphology	Metabolic endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Hyperplasia in pituitary gland	Neurological endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	400 mg/L	400 mg/L	Ovarian atrophy	Reproductive endocrine-mediated perturbations
	IVR	200 mg/L	200 mg/L	Changes in adrenal gland morphology	Metabolic endocrine-mediated perturbations
	IVR	200 mg/L	200 mg/L	Changes in morphology of pancreas	Metabolic endocrine-mediated perturbations
	IVR	200 mg/L	200 mg/L	Endometrial hyperplasia	Reproductive endocrine-mediated perturbations
	IVR	200 mg/L	200 mg/L	Ovarian atrophy	Reproductive endocrine-mediated perturbations
	IVR	200 mg/L	200 mg/L	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	200 mg/L	200 mg/L	Endometrial carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:17179639	IVR	1000 mg/L	1000 mg/L	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Affects survival of live fetus in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/L	1000 mg/L	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/L	500 mg/L	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	250 mg/L	-	No significant effects observed	-
	IVR	125 mg/L	-	No significant effects observed	-
PMID:6648426	IVR	500 mg/L	500 mg/L	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	500 mg/L	500 mg/L	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	500 mg/L	500 mg/L	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	500 mg/L	500 mg/L	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	500 mg/L	500 mg/L	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	500 mg/L	500 mg/L	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.