| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12003759 | IVTH | 0.0000000005 - 0.0005 M | 0.0000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 800 mg/kg | 800 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:15589235 | IVTH | 0.01 mmol/L | 0.01 mmol/L | Cancer phenotype | Endocrine-mediated cancer |
| PMID:15705771 | IVR | 0.7 mg/kg/day | 0.7 mg/kg/day | Affects uterine development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects uterine development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects uterine development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| PMID:16368123 | IVR | 285 mg | 285 mg | Increased LH levels | Reproductive endocrine-mediated perturbations |
| IVR | 285 mg | 285 mg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 285 mg | 285 mg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 285 mg | 285 mg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 285 mg | 285 mg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 59.3 mg | 59.3 mg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 59.3 mg | 59.3 mg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 59.3 mg | 59.3 mg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 59.3 mg | 59.3 mg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 59.3 mg | 59.3 mg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:17188730 | IVR | 24 mg/kg/day | 24 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:18174949 | IVR | 0.7 mg/kg/day | - | No significant effects observed | - |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Delayed puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Increased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Decreased prostate weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Decreased weights of epididymis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Increased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Delayed puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 47 mg/kg/day | 47 mg/kg/day | Decreased prostate weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Increased testis weights in offspring | Developmental endocrine-mediated perturbations;Re | |
| IVR | 7 mg/kg/day | 7 mg/kg/day | Delayed puberty | ||
| IVR | 7 mg/kg/day | 7 mg/kg/day | Decreased prostate weights in offspring | ||
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects expression of androgen receptor (AR) | ||
| IVR | 7 mg/kg/day | 7 mg/kg/day | Affects developmental process | ||
| PMID:18629307 | IVR | 7 mg/kg | 7 mg/kg | Increased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 7 mg/kg | 7 mg/kg | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg | 7 mg/kg | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg | 7 mg/kg | Increased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 7 mg/kg | 7 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| PMID:19885997 | IVR | 100 mg/kg/day | 100 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:21783972 | IVR | 100 mg/kg/day | 100 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| PMID:24004914 | IVTH | 0.00000001 - 0.00001 M | 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:28990245 | IVTH | 0.0000001 M | 0.0000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| IVTH | 0.0000001 M | 0.0000001 M | Induce cancer metastasis | Endocrine-mediated cancer | |
| IVTH | 0.00001 M | 0.00001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.