| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10630580 | IVR | 240 mg/kg/day | 240 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations |
| IVR | 240 mg/kg/day | 240 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:12242606 | IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:12927363 | IVR | 10 mg/kg/day | 10 mg/kg/day | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:18276755 | IVR | 2 mg/L | 2 mg/L | Abnormal neuronal distribution | Neurological endocrine-mediated perturbations |
| IVR | 2 mg/L | 2 mg/L | Affects neuronal density | Neurological endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Abnormal neuronal distribution | Neurological endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Affects neuronal density | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Affects neuronal density | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Abnormal neuronal distribution | Neurological endocrine-mediated perturbations | |
| PMID:20629314 | IVR | 5 mg/kg | 5 mg/kg | Alters thyroglobulin levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| PMID:21540284 | IVR | 3 mg/L | 3 mg/L | Changes in T-cell populations | Immunological endocrine-mediated perturbations |
| IVR | 3 mg/L | 3 mg/L | Decrease in Growth Hormone (GH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:28973696 | IVR | 2 mg/L | 2 mg/L | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVR | 2 mg/L | 2 mg/L | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/L | 2 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/L | 2 mg/L | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/L | 0.1 mg/L | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/L | 0.1 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/L | 0.5 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/L | 0.5 mg/L | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:29522169 | IVR | 5 mg/L | 5 mg/L | Increase in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/L | 5 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:29928935 | IVR | 5 mg/kg | 5 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated pertur | |
| PMID:30031104 | IVR | 0.05 % | 0.05 % | Increase in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 0.05 % | 0.05 % | Increased leptin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05 % | 0.05 % | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05 % | 0.05 % | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05 % | 0.05 % | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:30874585 | IVR | 10 mg/L | 10 mg/L | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 10 mg/L | 10 mg/L | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.