Tetrabromobisphenol A

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15635150	IVR	300 mg/kg/day	300 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:18255212	IVR	300 mg/kg/day	300 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
PMID:18313098	IVTH	0.000000005 - 0.0000005 M	0.0000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000005 - 0.0000005 M	0.0000005 M	Affects corticosterone metabolism	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:20399831	IVR	2100 mg/kg	2100 mg/kg	Decrease in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
PMID:25146423	IVR	0.035 mg/kg	0.035 mg/kg	Alters sperm function	Reproductive endocrine-mediated perturbations
	IVR	0.035 mg/kg	0.035 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:25223798	IVTH	0.000000001 - 0.0001 M	0.00000001 - 0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.00000001 - 0.0001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:26253174	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Decreased hCG levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:26979758	IVTH	0.001 M	0.001 M	Altered estrogen levels	Reproductive endocrine-mediated perturbations
PMID:28564613	IVR	20 mg/kg	-	No significant effects observed	-
	IVR	100 mg/kg	100 mg/kg	Affects neuronal density	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects neuronal density	Neurological endocrine-mediated perturbations
PMID:28616630	IVTH	0.000000000001 - 0.0001 M	0.0000005 - 0.000005 M	Cancer phenotype	Endocrine-mediated cancer

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