DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Dihexyl phthalate

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:19391110	IVR	750 mg/kg/day	750 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased Aspartate aminotransferase (AST) levels	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:19577633	IVR	250 mg/kg/day	250 mg/kg/day	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Nipple retention	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	-	No significant effects observed	-
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg/day	125 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg/day	125 mg/kg/day	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:25637754	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.