Diisobutyl phthalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:16458459	IVR	600 mg/kg/day	600 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Alterations in number of sertoli cells	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:18602967	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Lead to obesity in offspring	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:21633115	IVR	300 mg/kg/day	300 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	900 mg/kg/day	900 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:27513369	IVTH	0.0000001 - 0.00001 M	0.000001 - 0.00001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.000001 - 0.00001 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.000001 - 0.00001 M	Increase in estradiol/testosterone ratio	Reproductive endocrine-mediated perturbations
PMID:28081510	IVR	450 mg/kg/day	450 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:29191310	IVR	450 mg/kg/day	450 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Decreased estrogen levels	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	450 mg/kg/day	450 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.