Dicyclohexyl phthalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:12913283	IVTH	0.000001 - 0.001 M	0.00005 M	Cancer phenotype	Endocrine-mediated cancer
PMID:15379888	IVR	0.0000087 mmol	0.0000087 mmol	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.000000087 mmol	-	No significant effects observed	-
	IVR	0.000087 mmol	0.000087 mmol	Affects catecholamine biosynthesis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.000087 mmol	0.000087 mmol	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.00000087 mmol	0.00000087 mmol	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:15620428	IVR	0.087 M	0.087 M	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.087 M	0.087 M	Affects dopaminergic pathways	Neurological endocrine-mediated perturbations
PMID:15883486	IVTH	0.000000001 - 0.001 M	0.000001 - 0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:16641545	IVR	1200 mg/L	1200 mg/L	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	1200 mg/L	1200 mg/L	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	1200 mg/L	1200 mg/L	Affects morphology of hepatocytes	Hepatic endocrine-mediated perturbations
	IVR	1200 mg/L	1200 mg/L	Increased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Decreased spleen weights in offspring	Developmental endocrine-mediated perturbations;Immunological endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Decreased thymus gland weights in offspring	Developmental endocrine-mediated perturbations;Immunological endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Decreased brain weights in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	6000 mg/L	6000 mg/L	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	240 mg/L	240 mg/L	Decreased FSH levels	Reproductive endocrine-mediated p
PMID:19410640	IVR	20 mg/kg/day	-	No significant effects observed	-
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects testis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Nipple retention	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased weights of bulbocavernosus muscles/LABC	Reproductive endocrine-mediated perturbations
PMID:25637754	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations

---

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.