Sertraline

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:26162595	IVTH	0.000001 - 0.001 M	0.0000075 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.001 M	0.0000019 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.001 M	0.00000093 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:28179152	IVTH	0.00000001 - 0.0000075 M	0.000001 - 0.0000075 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 - 0.0000075 M	0.000001 - 0.0000075 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 - 0.0000075 M	0.000001 - 0.0000075 M	Increased estrogen/androgen ratio	Reproductive endocrine-mediated perturbations
PMID:29850907	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Increase in LH/Testosterone ratio	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Decreased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-m
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased 17-OH-progesterone levels
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased androstenedione levels
	IVR	5 mg/kg/day	5 mg/kg/day	Affects steroid metabolism
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased pregnenolone levels
	IVR	5 mg/kg/day	5 mg/kg/day	Decrease in corticosterone levels
	IVR	5 mg/kg/day	5 mg/kg/day	Affects steroidogenesis
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased 17-OH-pregnenolone levels
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased aldosterone levels
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased testosterone levels
	IVR	5 mg/kg/day	5 mg/kg/day	Increase in LH/Testosterone ratio
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased progesterone levels

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.