Diisopentyl phthalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:30031264	IVR	250 mg/kg/day	250 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg/day	125 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31368500	IVR	10 mg/kg/day	10 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of seminal vesicles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased weights of seminal vesicles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Atrophy in seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	-	No significant effects observed	-
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of seminal vesicles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Atrophy in seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations
	IVR	125 mg/kg/day	125 mg/kg/day	Affects steroidogenesis in offspring
PMID:31758603	IVR	10 mg/kg/day	10 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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