| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:21432428 | IVR | 10 % | 10 % | Altered DOPAC/DA ratio | Neurological endocrine-mediated perturbations |
| IVR | 10 % | 10 % | Decreased 5-HIAA/serotonin (5-HT) ratio | Neurological endocrine-mediated perturbations | |
| IVR | 20 % | 20 % | Altered DOPAC/DA ratio | Neurological endocrine-mediated perturbations | |
| IVR | 20 % | 20 % | Decreased 5-HIAA/serotonin (5-HT) ratio | Neurological endocrine-mediated perturbations | |
| IVR | 5 % | 5 % | Altered DOPAC/DA ratio | Neurological endocrine-mediated perturbations | |
| IVR | 5 % | 5 % | Decreased 5-HIAA/serotonin (5-HT) ratio | Neurological endocrine-mediated perturbations | |
| PMID:21463340 | IVR | 1000 mg/kg | 1000 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 1000 mg/kg | 1000 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 500 mg/kg | - | No significant effects observed | - | |
| IVR | 2000 mg/kg | 2000 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| PMID:611632 | IVR | 1.24 mg/kg/day | 1.24 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.62 mg/kg/day | - | No significant effects observed | - |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.