| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:11936222 | IVR | 10 mg/kg/day | 10 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.001 M | 0.000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:12737316 | IVTH | 0.0000001 - 0.00005 M | 0.0000025 - 0.0000038 M | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000001 - 0.00005 M | 0.00002 - 0.00005 M | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| PMID:12753421 | IVTH | 0.000000001 - 0.0001 M | 0.0001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:30817981 | IVTH | 0.00001 M | 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000001 M | 0.000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:9168009 | IVTH | 0.00001 M | 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.