Butyl p-hydroxybenzoate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:18602967	IVR	20 mg/kg/day	20 mg/kg/day	Lead to obesity in offspring	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:18648085	IVTH	0.00003 M	0.00003 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00003 M	0.00003 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00003 M	0.00003 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
PMID:20132880	IVR	62.5 mg/kg	62.5 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	62.5 mg/kg	62.5 mg/kg	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	62.5 mg/kg	62.5 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	62.5 mg/kg	62.5 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:22777679	IVR	62.5 mg/kg/day	62.5 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:24238989	IVR	1000 mg/kg	1000 mg/kg	Induce apoptosis of spermatogenic cells	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
PMID:24607685	IVR	400 mg/kg/day	400 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	160 mg/kg/day	-	No significant effects observed	-
	IVR	64 mg/kg/day	-	No significant effects observed	-
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
PMID:26888303	IVR	400 mg/kg/day	400 mg/kg/day	Altered germ cells morphology	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Altered germ cells morphology	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	64 mg/kg/day	-	No significant effects observed	-
	IVR	160 mg/kg/day	160 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:27120489	IVR	10 mg/kg	10 mg/kg	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:27122241	IVR	10 mg/kg/day	10 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	200 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	200 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	200 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	200 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:27135907	IVTH	0.00000001 - 0.00001 M	0.00000001 - 0.00001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:27535158	IVR	100 mg/kg/day	100 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:29350491	IVR	50 mg/kg	50 mg/kg	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects superoxide dismutase (SOD) levels	Hepatic endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Reduced sperm quality	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:29460325	IVTH	0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0001 M	0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:29945225	IVTH	0.00001 M	0.00001 M	Affects estrogen signaling	Reproductive endocrine-mediated perturbations
PMID:30218874	IVR	10 mg/kg/day	10 mg/kg/day	Affects folliculogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects fertility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of pituitary gland in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased hypothalamus weights in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of pituitary gland in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects folliculogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects implantation in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects fertility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Alterations in vaginal opening of offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of adrenal gland in offspring	D
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects uterine morphology in offspring
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects ovarian follicles population in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased uterine weights in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Affects implantation in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Alterations in vaginal opening of offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Affects folliculogenesis in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Affects fertility in offspring
PMID:30817981	IVTH	0.00000001 M	0.00000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:31195070	IVR	300 mg/kg/day	300 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	600 mg/kg/day	300 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	300 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	600 mg/kg/day	150 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	600 mg/kg/day	150 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:31672375	IVR	10 mg/kg/day	10 mg/kg/day	Changes in morphology of seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects expression of androgen receptor (AR) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Atrophy in seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Atrophy in seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Changes in morphology of seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased LH levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects expression of estrogen receptor-beta (ER-beta) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects implantation in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects steroidogenesis in offspring	D
	IVR	100 mg/kg/day	100 mg/kg/day	Affects implantation in offspring
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects testicular function in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels in offspring
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects spermatogenesis in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Affects sperm motility in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of pituitary gland in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Atrophy in seminiferous tubules in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in morphology of seminiferous tubules in offspring

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.