| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12419695 | IVR | 0.01 % | - | No significant effects observed | - |
| IVR | 0.1 % | 0.1 % | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:20132880 | IVR | 250 mg/kg | 250 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg | - | No significant effects observed | - | |
| PMID:22777679 | IVR | 62.5 mg/kg/day | 62.5 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.