| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:3881621 | IVR | 400 mg/L | 400 mg/L | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 200 mg/L | - | No significant effects observed | - | |
| IVR | 500 mg/L | 500 mg/L | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:716159 | IVR | 0.06 % | 0.06 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 0.06 % | 0.06 % | Hyperplasia in pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 0.03 % | 0.03 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Prostate atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Hyperplasia in pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.2 % | 0.2 % | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 % | 0.2 % | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 0.2 % | 0.2 % | Prostate atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 % | 0.2 % | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.2 % | 0.2 % | Hyperplasia in pituitary gland | Neurological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.