| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12594526 | IVR | 4000 mg/kg | 4000 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 300 mg/kg | 300 mg/kg | Hepatocellular carcinoma | Endocrine-mediated cancer;Hepatic endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Changes in morphology of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Hepatocellular carcinoma | Endocrine-mediated cancer;Hepatic endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 1000 mg/kg | 1000 mg/kg | Hepatocellular carcinoma | Endocrine-mediated cancer;Hepatic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | - | No significant effects observed | - | |
| IVR | 200 mg/kg | - | No significant effects observed | - | |
| IVR | 630 mg/kg | - | No significant effects observed | - | |
| IVR | 500 mg/kg | - | No significant effects observed | - | |
| IVR | 250 mg/kg | - | No significant effects observed | - | |
| IVR | 32 mg/kg | - | No significant effects observed | - | |
| IVR | 100 mg/kg | - | No significant effects observed | - | |
| IVR | 63 mg/kg | - | No significant effects observed | - |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.