| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:24607646 | IVR | 700 mg/kg/day | 700 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 140 mg/kg/day | 140 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Changes in epididymal morphology | Reproductive | |
| IVR | 700 mg/kg/day | 700 mg/kg/day | Affects testicular morphology | ||
| PMID:26866683 | IVR | 40 mg/kg/day | 40 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | - | No significant effects observed | - | |
| PMID:27892862 | IVR | 10 mg/kg | 10 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| Yin et al., 2014 | IVR | 50 mg/kg | 50 mg/kg | Affects the normal functioning of reproductive system | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | - | No significant effects observed | - | |
| IVR | 10 mg/kg | - | No significant effects observed | - |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.