Furan

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:31108444	IVR	40 mg/kg/day	40 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	40 mg/kg/day	40 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturb
	IVR	20 mg/kg/day	20 mg/kg/day	Reduced sperm counts
	IVR	5 mg/kg/day	5 mg/kg/day	Increased triglycerides level
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased cholesterol levels
	IVR	5 mg/kg/day	5 mg/kg/day	Increased cholesterol levels
PMID:31121209	IVR	10 mg/kg/day	10 mg/kg/day	Decreased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in Growth Hormone (GH) levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decrease in Growth Hormone (GH) levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increase in cortisol levels	Neurological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased triglycerides level	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.